Can You Get Lung Cancer Without Smoking

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Can You Get Lung Cancer Without Smoking – Lung cancer is the leading cause of death for both men and women in the United States. Most patients are in the final stages of the disease.

But there may be no symptoms, or the disease cannot be detected at the beginning. Some lung cancers do not show symptoms until they have spread. However, some people with early stage lung cancer may have symptoms and dismiss them as harmless.

Can You Get Lung Cancer Without Smoking

In the early stages, the symptoms of lung cancer are not clear. For example, chronic cough should not be ignored, doctors.

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Although smoking contributes to the majority of lung cancers, there are other risk factors such as exposure to secondhand smoke, breathing radon (natural gas), exposure to asbestos or other cancer-causing chemicals in the workplace, and air pollution. The dirt

Although lung cancer screening is focused on high-risk patients, it can happen to anyone. No one is at risk of developing lung cancer.

If you go to your doctor when you first see symptoms, the earlier your cancer can be caught, the more effective the treatment will be. About 70 percent of lung cancer cases progress to stage 3 (25 percent) or stage 4 (45 percent). Stage 4 is the most advanced stage of lung cancer. At that time, the cancer has usually spread to both lungs, the fluid around the lungs, or other parts of the body, such as the liver or other organs.

But even for serious diseases, there are effective treatment methods. In general, most treatments are available for small cell lung cancer, which accounts for 85 percent of cases.

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Most of these symptoms are caused by something other than lung cancer. But if you have any kind of problem, it is important to see your doctor and get treatment if necessary.

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Lung cancer is the leading cause of cancer death among men and women in the United States and Utah. Colon, prostate, ovarian, and breast cancers combined kill many people every year. Learn about the risks of non-smokers so you can take steps to prevent or reduce your risk of lung cancer.

Some conditions cannot be changed, such as existing lung disease, previous cancer, and a family history of lung cancer. But you can still take steps to reduce your risk.

Lung cancer can develop for years without symptoms. For this reason, it is often not confirmed until it reaches a high level. Contact your doctor if you have any of the following symptoms.

You may have these symptoms but not have lung cancer. Get to know your body and watch for unusual changes. Even if you don’t have any symptoms, talk to your doctor to find out if there are any signs of lung cancer. If you have lung cancer, this can help you and your doctor find it early, when treatment is most effective.

Risk Factors For Lung Cancer

If you have more questions about the risk of lung cancer, contact the Cancer Education Center of the Hantman Cancer Institute: Smoking is the main cause of lung cancer, but only a small percentage of smokers develop the disease. A study by scientists at the Albert Einstein College of Medicine published online on April 11, 2022

It suggests that some smokers may have stronger mechanisms to prevent lung cancer by limiting smoking. Research can help identify smokers who are at higher risk of developing the disease and should be monitored closely.

“This could be an important step in the prevention and early detection of lung cancer, diverting expensive and painful efforts to fight chronic diseases,” said Simon Spivak, MD. , MPH, the study’s senior author, is the Einstein Professor of Medicine, Epidemiology and Public Health and Genetics and Pulmonology at Montefiore Health System.

Smoking is thought to cause lung cancer by causing DNA changes in normal lung cells. But this cannot be confirmed until our study because there is no direct way to detect changes in normal cells,” said senior author Jan Vijg, Ph. of molecular genetics at Einstein (also Center for Single-Cell Omics, Jiaotong University School Medical in Shanghai, China) Dr. Won. A few years ago he made a complete sequence of the cells of a single cell of that problem, Vijg.

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Whole-genome sequencing methods can reveal sequence errors that are difficult to distinguish from true mutations—a serious problem when examining cells with rare mutations. Dr. We have addressed this problem by developing a new serial method called single cell multiple displacement (SCMDA). As mentioned

Einstein researchers used SCMDA to measure changes in the appearance of normal lung epithelial cells (ie, lung epithelial cells) from two types of people: 14 smokers, ages 11 to 86; And 19 smokers aged 44 to 81, smoked 116 pack years. (A pack-year of smoking is equivalent to 1 cigarette per day for a year.) Tissues were collected from patients who underwent bronchoscopy for non-cancer-related diagnostic tests. These lung cells have been around for years or even decades, and they can accumulate with age and smoking,” said Dr. “Of all the lung cells, these are the most likely to become cancerous,” Spivak said.

The researchers found that mutations (single-nucleotide sequences and small additions and deletions) accumulated with age in the lung cells of non-smokers—and more mutations were found in the lung cells of smokers. “This test confirms that smoking increases the risk of lung cancer by increasing the number of mutations, as previously thought,” said Dr. “This appears to be one of the reasons why so few non-smokers develop lung cancer, compared to 10% to 20% of lifetime smokers,” said Spivak.

Another research result: the number of cell mutations found in lung tissue increases in a direct line with four years of smoking – and possibly increases the risk of lung cancer. But what is interesting is that the increase in cell turnover stopped after 23 years of exposure.

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“Heavier smokers did not have a greater burden of change,” said Dr. Spivak said, “Our data shows that even though these people smoked a lot, they were able to live longer because they were able to control the accumulation of mutations. There are specific ways to repair or clean up damaged DNA. these remove this change.

The study led to new research. “Now we want to develop new tests to measure a person’s ability to repair or purify DNA, which will provide a new way to assess a person’s risk of developing lung cancer,” said Dr. Vijg.

Abstract: “Single Cell Analysis of Somatic Changes in Human Bronchial Epithelial Cells Associated with Aging and Smoking” by Zhenqiu Huang, Shixiang Sun, Moonsok Lee, Alexander Y. Maslov, Miao Shi, Spencer Waldman, Ava Marsh, Taha Siddiqui, Xiao Dong, Yaakov Peter, Ali Sadughi, Chirag Shah, Kenny Ye, Simon D. Spivak and Jan Vij, 11 April 2022;

The study is titled “Single-cell analysis of somatic changes in human bronchial epithelial cells associated with aging and smoking.” Other Einstein authors include: Zhenqiu Huang, Ph.D., Shixiang Sun, Ph.D., Moonsok Lee, M.S., Yakov Peter, Ph.D., Ali Sadhugi, MD, Chirag Shah, MD. and Kenny Yeh, Ph.D. D., Miao Shi, Ph.D., Spencer Waldman, B.S., Ava Marsh, BA, Taha Siddiqui, MBS., Alexander Y. Maslov, MD, Ph.D. (also Voronezh State University of Engineering Technology, Voronezh, Russia) and Xiao Dong, Ph.D. (Also University of Minnesota, Minneapolis, MN.)

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This research was supported by grants from the National Institutes of Health (U01 ES029519-01, U01HL145560, AG017242, and AG056278).

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Lung Cancer: Smokers And Non Smokers Are At Risk

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